Congenital afibrinogenemia is a rare, inherited blood disorder in which the blood does not clot normally. It occurs when there is a total lack of a protein called fibrinogen. This protein is needed for the blood to
This rare disease is due to an abnormal gene that causes a complete lack of fibrinogen. The gene must be passed down from both parents.
Congenital afibrinogenemia can occur in males or females.
Milder forms can occur in people who inherit only one abnormal gene from their parents.
Call your health care provider or seek emergency care if you have excessive bleeding.
Tell your surgeon before you have surgery if you know or suspect you have a bleeding disorder.
Congenital afibrinogenemia is an inherited condition. There is no known prevention.
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Meeks SL. Congenital disorders of fibrinogen. In: Shaz BH, Hillyer CD, Roshal M, Abrams CS, eds. Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects. 2nd ed. Philadelphia, PA: Elsevier; 2013:chap 108.
Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.