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Hyperimmunoglobulin E syndrome

Definition

Hyperimmunoglobulin E syndrome is a rare, inherited disease. It causes problems with the skin, sinuses, lungs, bones, and teeth.

Alternative Names

Job syndrome; Hyper IgE syndrome

Causes

Hyperimmunoglobulin E syndrome is also called Job syndrome. It is named after the biblical character Job whose faithfulness was tested by an affliction with draining skin sores and pustules. People with this condition have long-term, severe skin infections.

The symptoms are most often present in childhood, but because the disease is so rare, it often takes years before a correct diagnosis is made.

Recent research suggests that the disease is often caused by a genetic change (mutation) that takes place in the STAT3 gene on chromosome 4. How this gene abnormality causes the symptoms of the disease is not well understood. However, people with the disease have a higher-than-normal level of an antibody called IgE.

Symptoms

Symptoms include:

  • Bone and tooth defects, including fractures and losing the baby teeth late
  • Eczema
  • Skin abscesses and infection
  • Repeated sinus infections
  • Repeated lung infections

Exams and Tests

An eye exam may reveal signs of dry eye syndrome. A physical exam may also show:

A chest x-ray may reveal lung abscesses.

Tests used to confirm the diagnosis include:

Other tests that may be done:

A scoring system that combines the different problems of Hyper IgE syndrome is used to help make the diagnosis.

Treatment

There is no known cure for this condition. The goal of treatment is to control the infections. Medicines include:

  • Antibiotics
  • Antifungal and antiviral medicines (when appropriate)

Sometimes, surgery is needed to drain abscesses.

Gamma globulin given through a vein (IV) may help build up the immune system if you have severe infections.

Outlook (Prognosis)

Hyper IgE syndrome is a lifelong chronic condition. Each new infection requires treatment.

Possible Complications

Complications may include:

When to Contact a Medical Professional

Call your health care provider if you have symptoms of Hyper IgE syndrome.

Prevention

There is no proven way to prevent Hyper IgE syndrome. Good general hygiene is helpful.

Some providers may recommend preventive antibiotics for people who develop many infections, especially with Staphylococcus aureus. This treatment does not change the condition, but it can lessen its complications.

References

Fischer A. Primary Immune Deficiency Diseases. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J. eds. Harrison's Principles of Internal Medicine. 19th ed. New York, NY: McGraw-Hill; 2015;chap 374.

Hsu AP, Davis J, Puck JM, et al. Autosomal dominant hyper IgE syndrome. Gene Reviews. Seattle, WA: University of Washington; 2012;6. PMID: 20301786 www.ncbi.nlm.nih.gov/pubmed/20301786. Accessed August 1, 2015.


Review Date: 8/1/2015
Reviewed By: Chad Haldeman-Englert, MD, FACMG, Fullerton Genetics Center, Asheville, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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