An examination of the blood shows teardrop-shaped red blood cells and immature white blood cells. Bone marrow biopsy is usually needed to make the diagnosis and to rule out other causes of the symptoms.
In the past, the treatment of myelofibrosis has depended on the symptoms and degree of the low blood counts.
In young people, bone marrow or stem cell transplantation appears to improve the outlook, and may cure the disease. A long-term (5 year) remission is possible for some patients with bone marrow transplantation. Such treatment should be considered for younger patients and some others.
Other treatment may involve:
Blood transfusions and medicines to correct anemia
Make an appointment with your health care provider if you have symptoms of this disorder. Uncontrolled bleeding, shortness of breath, or jaundice (yellow skin and whites of the eyes) that gets worse need urgent or emergency care.
Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.