Rhabdomyolysis is the breakdown of muscle tissue that leads to the release of muscle fiber contents into the blood. These substances are harmful to the kidney and often cause kidney damage.
When muscle is damaged, a protein called myoglobin is released into the bloodstream. It is then filtered out of the body by the kidneys. Myoglobin breaks down into substances that can damage kidney cells.
Rhabdomyolysis may be caused by injury or any other condition that damages skeletal muscle.
Problems that may lead to this disease include:
Trauma or crush injuries
Use of drugs such as cocaine, amphetamines, statins, heroin, or PCP
Call your provider if you have symptoms of rhabdomyolysis.
Drink plenty of fluids after strenuous exercise. This will help to dilute your urine and flush any myoglobin that is released from your muscles out of your kidneys. Also drink a lot of fluids after any condition that may have damaged skeletal muscle.
Shafuddin AA, Weisbord SD, Palevsky PM, et al. Acute kidney injury. In: Taal MW, Chertow GM, Marsden PA, et al, eds. Brenner and Rector's The Kidney. 9th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 30.
Charles Silberberg, DO, private practice specializing in nephrology, Affiliated with New York Medical College, Division of Nephrology, Valhalla, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.