IgA nephropathy is a kidney disorder in which antibodies called IgA build up in kidney tissue. Nephropathy is damage, disease, or other problems with the kidney.
IgA nephropathy is also called Berger disease.
Nephropathy - IgA; Berger disease
IgA is a protein, called an antibody, that helps the body fight infections. IgA nephropathy occurs when too much of this protein is deposited in the kidneys. IgA builds up inside the small blood vessels of the kidney. Structures in the kidney called glomeruli become inflamed and damaged.
You may get medicines to control high blood pressure and swelling (edema), such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). Controlling blood pressure is the most important way to delay kidney damage.
Corticosteroids, other drugs that suppress the immune system, and fish oil have also been used to treat this disorder.
Salt and fluids may be restricted to control swelling. A low-to-moderate protein diet may be recommended in some cases.
Some people need to take medicines to lower their cholesterol.
Eventually, many people must be treated for chronic kidney disease and may need dialysis.
For additional information and support, see the IgA Nephropathy Support Network website (www.igansupport.org).
IgA nephropathy gets worse slowly. In many cases, it does not get worse at all. Your condition is more likely to get worse if you have:
Charles Silberberg, DO, private practice specializing in nephrology, affiliated with New York Medical College, Division of Nephrology, Valhalla, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.