Adult Still's disease is a rare illness that causes high fevers, rash, and joint pain. It may lead to long-term (chronic) arthritis.
Still's disease is a severe version of juvenile idiopathic arthritis (JIA), which occurs in children. Adults can have the same condition although it is much less common. It is also called adult-onset Still's disease (AOSD).
Still's disease - adult; AOSD
Fewer than 1 out of 100,000 people develop adult-onset Still's disease each year. It affects women more often than men.
The cause of adult Still's disease is unknown. No risk factors for the disease have been identified.
Almost all people with the disease will have fever, joint pain, sore throat, and a rash.
Joint pain, warmth, and swelling are common. Most often, several joints are involved at the same time. Often, people with the condition have morning stiffness of joints that lasts for several hours.
The fever comes on quickly once per day, most commonly in the afternoon or evening.
The skin rash is often salmon-pink colored and comes and goes with the fever.
Additional symptoms include:
Abdominal pain and swelling
Pain when taking a deep breath (pleurisy)
Swollen lymph nodes (glands)
The spleen or liver may become swollen. Lung and heart inflammation may also occur.
Exams and Tests
Adult-onset Still's disease can only be diagnosed after many other diseases (such as infections and cancer) are ruled out. You may need many medical tests before a final diagnosis is made.
A physical exam may show a fever, rash, and arthritis. The health care provider will use a stethoscope to listen for changes in the sound of your heart or lungs.
The following blood tests can be helpful in diagnosing adult Still's disease:
Complete blood count (CBC), may show a high number of white blood cells and reduced number of red blood cells.
Call your health care provider if you have symptoms of adult-onset Still's disease.
If you have already been diagnosed with the condition, you should call your provider if you have a cough or difficulty breathing.
Clarke JT. Other Rheumatologic Diseases. In: Bolognia JL, Jorizzo JL, Schaffer JV, et al, eds. Dermatology. 3rd ed. Philadelphia, PA: Elsevier Mosby; 2012:chap 45.
Gerfaud-Valentin M, Maucort-Boulch D, Hot A, et al. Adult-onset still disease: manifestations, treatment, outcome, and prognostic factors in 57 patients. Medicine (Baltimore). 2014;93:91. PMID: 24646465 www.ncbi.nlm.nih.gov/pubmed/24646465.
Lee LA, Werth VP. The Skin and Rheumatic Diseases. In: Firestein GS, Budd RC, Gabriel SE, et al, eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 43.
Gordon A. Starkebaum, MD, professor of medicine, division of rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.