Treatment begins with plenty of fluids and electrolytes. Replacement of folate, iron, vitamin B12, and other nutrients may also be needed. Antibiotic therapy with tetracycline or Bactrim is typically given for 3 to 6 months.
In most cases, oral tetracycline is not prescribed for children until after all the permanent teeth have come in. This medicine can permanently discolor teeth that are still forming. However, other antibiotics can be used.
The outcome is good with treatment.
Vitamin and mineral deficiencies are common.
In children, sprue leads to:
Delay in the maturing of bones (skeletal maturation)
Tropical sprue symptoms get worse or do not improve with treatment
You develop new symptoms
You have diarrhea or other symptoms of this disorder for a long period of time, especially after spending time in the tropics
Other than avoiding living in or traveling to tropical climates, there is no known prevention for tropical sprue.
Semrad CE. Approach to the patient with diarrhea and malabsorption. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 142.
Todd Eisner, MD, private practice specializing in gastroenterology, Boca Raton, FL. Affiliate Assistant Professor, Florida Atlantic University School of Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.